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缺血性脑血管病系老年多发病、常见病,本文应用抗血小板凝集剂-阿斯匹林、潘生丁及低分子右旋糖酐(下简称低右)治疗缺血性脑梗塞100例及单纯应用低右54例作对照,均住院一个疗程治疗观察。结果治疗组近期总有效率89%,其中老年前期及老年期总有效率分别为90.91%、86.67%;对照组分别为64.81%、68.75%及54.55%,P值分别<0.01、<0.01、<0.05,均有非常显著与显著差异。男女性别无显著差异。随访92例,随访期1--51个月,平均32.7±1.2个月,治疗组56例中2例复发,对照组9例复发,复发率分别为3.57%与25%,P<0.01,有非常显著差异,提示其远期疗效明显。本文探讨了抗血小板凝集剂作用机理最佳剂量,阿斯匹林0.5,1/日;潘生丁50mg,3/日,是治疗缺血性脑梗塞的理想药物和最佳剂量。
Ischemic cerebrovascular disease in the elderly frequently-occurring disease, common disease, the application of anti-platelet aggregation agent - aspirin, dipyridamole and low molecular weight dextran (hereinafter referred to as low right) for the treatment of 100 cases of ischemic cerebral infarction and simple application of low right 54 cases as a control, were hospitalized for a course of treatment observation. Results The total effective rate in the treatment group was 89%, the total effective rates in pre-senile and senile patients were 90.91% and 86.67% respectively; the control group was 64.81%, 68.75% and 54.55% respectively, P values were <0.01, <0.01, 0.05, there are very significant and significant differences. There was no significant difference between men and women. The follow-up was performed in 92 cases, followed up for 1--51 months with an average of 32.7 ± 1.2 months. Two of 56 patients in the treatment group relapsed, and 9 patients in the control group relapsed with recurrence rates of 3.57% and 25%, respectively, P <0.01 Very significant difference, suggesting that its long-term effect is obvious. This article discusses the best dose of antiplatelet agent mechanism of action, aspirin 0.5,1 / day; dipyridamole 50mg, 3 / day, is the ideal drug for the treatment of ischemic cerebral infarction and the optimal dose.