论文部分内容阅读
目的:探讨芍甘多苷(DSM)对多种实验性肝损伤的保护作用。方法:分别采用四氯化碳(CCl4)、D-氨基半乳糖(D-GalN)诱发小鼠化学性急性肝损伤,内毒素+卡介苗(LPS+BCG)诱发小鼠免疫性肝损伤,然后灌胃给予不同剂量的DSM,每天1次,连续4天,观察药物对血清转氨酶和肝脏病理形态的影响。结果:模型组小鼠血清转氨酶及肝脏病理组织学评分明显增高,DSM组血清转氨酶,肝脏病理组织学评分有不同程度的降低。结论:DSM能减轻化学性和免疫性肝损伤,具有明显的保肝作用。
Objective: To investigate the protective effects of polyglucoside (DSM) on a variety of experimental liver injury. Methods: Chemical acute liver injury was induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice, and immunological liver injury was induced by LPS + BCG in mice. The stomach was given different doses of DSM, once a day for 4 consecutive days to observe the effects of drugs on serum aminotransferase and liver pathology. Results: Serum aminotransferase and histopathological scores in model group were significantly higher than those in model group. Serum aminotransferase and hepatic histopathological scores of DSM group decreased to some extent. Conclusion: DSM can reduce the chemical and immune liver injury, with obvious liver protection.