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目的:研究玄归止痛滴丸对气血淤滞所致疼痛的药效学。方法:取玄归止痛滴丸用新沸过的蒸馏水配置3个剂量组(相当于原生药0.25、0.5、1g.kg-1),灌胃给药,比较在活血、止痛、抗炎、常压耐缺氧功能及改善血淤模型的血液流变学指标方面,玄归止痛滴丸对模型动物的影响。结果:玄归止痛滴丸对模型小鼠有显著的镇痛、抗炎、抗凝血及常压下耐缺氧作用;玄归止痛滴丸对寒凝血淤证模型兔血液的黏、浓、凝、聚状态也有显著改善。结论:玄归止痛滴丸有显著的镇痛作用和一定的活血作用。
OBJECTIVE: To study the pharmacodynamics of Xuanguizhitao dripping pills on the pain caused by qi-blood stasis. Methods: Take XuanGuiZhiTong dripping pills with new boiling over distilled water configuration 3 dose group (equivalent to the native drug 0.25,0.5,1 g.kg-1), intragastric administration, more in the blood, pain, anti-inflammatory, often Xuan Guizhi Tong drop pills on model animals in terms of pressure resistance to hypoxia and blood hemorheology indicators to improve blood stasis model. Results: XuanGuiZhiTong dripping pill had obvious analgesia, anti-inflammation, anticoagulant and anti-hypoxia effect in model mice; XuanGuiZhiTong dripping pills had no effect on blood viscosity, Condensed, poly state has also been significantly improved. Conclusion: Xuanguizhe Dripping Pill has significant analgesic effect and certain blood activating effect.