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目的 :模拟研究人体心脏舒张早期潜存的心室最大负压。方法 :先在血液循环体外模拟装置上模拟正常生理情况下的左、右心室心动周期压力曲线 ,然后近似阻断房室通道 ,分别测定左、右心室压力。结果 :模拟实验得到的左、右心室心动周期压力曲线和正常生理情况下的左、右心室心动周期压力曲线非常接近。近似阻断房室瓣时 ,左、右心室舒张的负压平均值分别是 - 93.2 5mmHg(- 12 .4 3kPa)和 - 10 .2 8mmHg(- 1.37kPa)。结论 :模拟得到的实验结果可以定性地说人体心脏舒张和静脉血液回流心生物动力学关系 ;心脏舒张时心室压力的减低 (负压 )是形成静脉 -心房 -心室压力梯度的根本原因 ,心脏舒张所产生的舒张吸力是静脉血液回流心室的主要动力 ,即静脉血液回流心脏是心脏舒张吸力作用的结果 ;心脏前负荷产生的机理应该是心脏舒张抽吸静脉血液回流心脏所需的吸力。静脉血液在被抽吸回流心室腔的过程中对心室肌没有伸展作用 ,即Starling心定律没有心脏舒张动力学基础
Objective: To simulate the maximal negative ventricular pressure in the early diastole of human heart. Methods: The left and right ventricular cardiac pressure curve under normal physiological conditions were simulated on the blood circulation in vitro simulation device, and then the atrioventricular channels were blocked approximately and the left and right ventricular pressure were measured respectively. Results: The left and right ventricular cardiac cycle pressure curves obtained by the simulation experiment are very close to the left and right ventricular cardiac cycle pressure curves under normal physiological conditions. Approximately atrioventricular valve closure, left and right ventricular diastolic negative pressure were - 93.2 5mmHg (- 12 .4 3kPa) and - 10 .28 mmHg (-1.37kPa). CONCLUSIONS: The experimental results obtained from the simulation can be used to qualitatively describe the relationship between the diastolic venous blood flow and cardiac biokinetics. The decrease of ventricular pressure (negative pressure) during diastole is the underlying cause of venous-atrial-ventricular pressure gradient. Diastolic The resulting diastolic suction is the main driving force behind the venous return vena cava, ie the venous return heart is the result of diastolic suction; the mechanism of preload of the heart should be the suction required for diastolic aspiration of the venous blood returning to the heart. Venous blood has no extension to the ventricular muscle during aspiration of the ventricular return, which means that the Starling’s law does not have a basis for cardiac diastolic kinetics