论文部分内容阅读
为确定急性脑梗塞（ Ａ Ｃ Ｉ） 是否存在对髓鞘素碱性蛋白（ Ｍ Ｂ Ｐ） 、髓鞘素结合糖蛋白（ Ｍ Ａ Ｇ） 和含脂质蛋白（ Ｐ Ｌ Ｐ） 的 Ｂ 细胞免疫应答，采用酶联免疫斑点（ Ｅ Ｌ Ｉ Ｓ Ｐ Ｏ Ｔ） 技术检测了发病后４周内的 Ａ Ｃ Ｉ和其它神经疾病（ Ｏ Ｎ Ｄ） 对照组患者外周血和脑脊液（ Ｃ Ｓ Ｆ） 的 Ｍ Ｂ Ｐ、 Ｍ Ａ Ｇ 和 Ｐ Ｌ Ｐ 抗体分泌细胞。发现 Ａ Ｃ Ｉ和 Ｏ Ｎ Ｄ 外周血检出的 Ｉｇ Ｇ、 Ｉｇ Ａ、 Ｉｇ Ｍ 三种表型 Ｍ Ｂ Ｐ、 Ｍ Ａ Ｇ 和 Ｐ Ｌ Ｐ 抗体分泌细胞数无显著差异，但 Ａ Ｃ Ｉ患者 Ｃ Ｓ Ｆ 的 Ｉｇ Ｇ 型 Ｍ Ｂ Ｐ、 Ｍ Ａ Ｇ 和 Ｐ Ｌ Ｐ 抗体分泌细胞数呈显著性增高。推测 Ａ Ｃ Ｉ的缺血损伤可导致 Ｃ Ｎ Ｓ内 Ｂ 细胞激活及对髓鞘素抗原的 Ｂ 细胞免疫应答，其病理意义尚有待探讨。
To determine whether acute mycotic infarction (AIC) is immunized against myelin basic protein (M B P), myelin-binding glycoprotein (M A G), and lipoprotein (P L P) -containing B cells Response, the levels of peripheral blood and cerebrospinal fluid (CSF) in patients with ACI and other neurologic disease (O N D) controls within 4 weeks after onset of disease were measured using ELISPOT technique M B P, M A G and P L P antibody secreting cells. Found that there was no significant difference in the number of secreted cells of M B P, M A G and P L P between the three phenotypes of Ig G, Ig A and Ig M detected in peripheral blood of A C I and O N D, The number of secreted cells of Ig G M B P, M A G and P L P of S F was significantly increased. It is hypothesized that the ischemic injury of A C I can lead to the activation of B cells in C N S and the B cell immune response to myelin antigens. The pathological significance remains to be explored.