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目的:评价氯沙坦联合胺碘酮对阵发性心房颤动(房颤)的疗效。方法:124例阵发性房颤随机分为Ⅰ组(胺碘酮)、Ⅱ组(胺碘酮+氯沙坦),观察房颤转复率、窦性心律维持率及左心房内径。结果:治疗后7 d房颤转复率Ⅰ组为84.48%,Ⅱ组为94.44%。随访1 a时窦性心律维持率Ⅰ组为70.24%,Ⅱ组为86.48%(P<0.05);左心房内径Ⅰ组为(38.25±1.52)mm,Ⅱ组为(35.12±1.46)mm(P<0.05)。结论:氯沙坦联合胺碘酮对阵发性房颤的复律及复律后窦性心律的维持均优于单用胺碘酮,并能抑制左心房扩大。
Objective: To evaluate the efficacy of losartan combined with amiodarone on paroxysmal atrial fibrillation (AF). Methods: A total of 124 patients with paroxysmal atrial fibrillation were randomly divided into group Ⅰ (amiodarone) and group Ⅱ (amiodarone + losartan). The recovery rate of atrial fibrillation, the maintenance rate of sinus rhythm and the diameter of the left atrium were observed. Results: At 7 days after treatment, the recovery rate of atrial fibrillation was 84.48% in group I and 94.44% in group Ⅱ. The follow-up of 1-year sinus rhythm maintenance rate was 70.24% in group Ⅰ and 86.48% in group Ⅱ (P <0.05). The left atrial diameter was (38.25 ± 1.52) mm in group Ⅰ and (35.12 ± 1.46) mm in group Ⅱ <0.05). Conclusion: Losartan combined with amiodarone on paroxysmal atrial fibrillation and sinus rhythm after cardioversion were better than single amiodarone, and can inhibit the expansion of the left atrium.