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近年来,除ANA、SMA、AMA外又相继发现了一些新的自身抗体:LSP、LMA、LKM-1、ASGPR、LCI、SLA、LP抗体等,随着对自身免疫性肝炎(AIH)的亚型分类、遗传背景与发病、与HCV感染的关系等的阐明,得出了该病的新概念:AIH是一组慢性肝炎综合征,病人呈现肝脏本身的免疫耐受性减低,不能正确识别自身肝组织成分而产生自身免疫反应,引起以门脉周围病变为主的非自限性肝炎。目前将其分为3型:①AIH-Ⅰ型,即经典型,主要为ANA或SMA(或actin抗体)阳性,最近又细分为Ⅰa型(ANA阳性)与Ⅰb型(actin抗体阳性);②AIH-Ⅱ型主要为LKM-1抗体阳性,或同时有LCI抗体,近又细分为Ⅱ
In recent years, new autoantibodies such as LSP, LMA, LKM-1, ASGPR, LCI, SLA and LP antibodies have been found in addition to ANA, SMA and AMA. With the development of subtypes of autoimmune hepatitis (AIH) Type classification, genetic background and incidence, the relationship with HCV infection and other elucidation of the disease, reached a new concept of the disease: AIH is a group of chronic hepatitis syndrome, the patient showed reduced immune tolerance of the liver itself, can not correctly identify themselves Liver tissue components and produce autoimmune reactions, causing lesions around the portal vein-based non-self-limiting hepatitis. Currently it is divided into three types: ①AIH-Ⅰ type, the classic, mainly ANA or SMA (or actin antibody) positive, and recently subdivided into Ⅰ a type (ANA positive) and Ⅰ b type (actin antibody positive); ② AIH -II type is mainly positive for LKM-1 antibody, or LCI antibodies at the same time, and then subdivided into Ⅱ