论文部分内容阅读
目的研究临床分离的铜绿假单胞菌感染分布及其耐药性,为临床医师合理使用抗菌药物提供参考。方法采用细菌分离鉴定技术和药敏试验方法,对某医院住院及门诊患者送检的病原学标本进行细菌检测与评价。结果从该医院临床送检标本中共分离出铜绿假单胞菌506株,主要分离自痰液、分泌物和尿液标本,构成比依次为68.8%、11.7%和9.1%。送检标本数量居前3位的科室分别是重症监护病房、呼吸内科和脑外科,构成比依次为24.3%、22.7%和15.0%。临床分离的铜绿假单胞菌对所试验的14种抗菌药物全部产生不同程度耐药,耐药率最低的是妥布霉素、阿米卡星和庆大霉素。结论该医院临床分离出的铜绿假单胞主要为呼吸道感染,对临床常用抗菌药物均不同程度耐药,应加强耐药菌监测和抗菌药物管理。
Objective To study the distribution of clinical isolates of Pseudomonas aeruginosa and their drug resistance and provide reference for rational use of antibacterial drugs by clinicians. Methods Bacterial isolation and identification techniques and drug susceptibility testing methods were used to detect and evaluate the bacteria in etiological specimens of inpatients and outpatients in a hospital. Results A total of 506 strains of Pseudomonas aeruginosa were isolated from the clinical specimens of the hospital, mainly from sputum, secretions and urine samples, with the proportions of 68.8%, 11.7% and 9.1%, respectively. The top three departments of the submitted specimens were ICU, respiratory medicine and brain surgery, with the proportions of 24.3%, 22.7% and 15.0%, respectively. Pseudomonas aeruginosa isolated from clinical isolates all had different levels of resistance to the 14 antibacterials tested, the least resistant rates were tobramycin, amikacin and gentamicin. Conclusions The clinical isolates of Pseudomonas aeruginosa isolated from this hospital are mainly respiratory tract infections. They are resistant to different levels of commonly used antibiotics in clinical practice. Drug-resistant bacteria should be monitored and the management of antibiotics should be strengthened.