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根据FAB协作组的标准,急性早幼粒细胞白血病(APL)的诊断只有在大量的细胞为异常早幼粒细胞、胞浆充满粗颗粒,同时具有明显Auer小体的情况下才能确定。临床方面,APL为急白的一种形式,其特点为伴有出血与弥漫性血管内凝血(DIC)。细胞遗传学方面,已识别APL患者有特异的染色体异常[t(15;17)],这种易位在FAB分类法的其它任何一种急白中,尚未见报导。本文对3名以FAB分类法为M_2的患者进行光镜、细胞化学、电镜和染色体分析。结果如下:光镜下3例患者骨髓多颗粒早幼粒细胞<50%,尘样细颗粒细胞分别为22、45、62%,>50%的细胞类似于单核细胞
According to the criteria of the FAB collaboration group, the diagnosis of acute promyelocytic leukemia (APL) can only be confirmed when a large number of cells are abnormally promyelocytic, the cytoplasm is filled with coarse particles, and there are apparent Auer bodies. Clinically, APL is a form of acute whiteness characterized by bleeding and diffuse intravascular coagulation (DIC). In terms of cytogenetics, patients with APL have been identified as having specific chromosomal abnormalities [t(15;17)]. This translocation has not been reported in any of the other acute whites of the FAB classification. In this paper, three patients with FAB classification M2 were examined by light microscopy, cytochemistry, electron microscopy, and chromosome analysis. The results are as follows: Light microscopy 3 cases of bone marrow multigrain promyelocytic cells <50%, dust-like fine-grain cells were 22, 45, 62%,> 50% of cells similar to monocytes