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目的：比较静脉滴注5 -单硝异山梨醇酯（5-ISMN）与二硝酸异山梨醇酯（ISDN）注射液对充血性心力衰竭患者的疗效及血液动力学的影响。方法：采用随机，单盲的方法，将63例患者分成两组，分别给予 5-单硝异山梨醇酯和二硝酸异山梨醇酯注射液20mg；测定两组病人用药前、后血压、心率、心功能及血液动力学指标。结果：5-单硝异山梨醇酯和二硝酸异山梨醇酯注射液显效率分别为43.75%和48.38%，总有效率分别为93.75%和96.76%，治疗后两组疗效显著，两组间无显著性差异。两药均有降低血压、心率，增加心排血量，改善心功能的作用。5-单硝异山梨醇酯治疗后，肺毛细血管楔嵌压、肺动脉平均压、右房压等指标下降。结论：5-单硝异山梨醇酯注射液与二硝酸异山梨醇酯注射液相同，对充血性心力衰竭有显著疗效。
OBJECTIVE: To compare the efficacy and hemodynamics of 5-isonosorbide 5-ISMN and ISDN injection in patients with congestive heart failure. Methods: A total of 63 patients were divided into two groups according to a randomized, single-blind method. The patients were given 5-NPIS and 20 mg isosorbide dinitrate injection respectively. Before and after treatment, blood pressure, heart rate , Cardiac function and hemodynamic parameters. Results: The effective rates of 5-mononitration isosorbide and isosorbide dinitrate injection were 43.75% and 48.38%, respectively. The total effective rates were 93.75% and 96.76% respectively. After treatment, the curative effect was significant in both groups. No significant difference. Both drugs have lower blood pressure, heart rate, increased cardiac output, improve cardiac function. 5-mononitration isosorbide ester treatment, pulmonary capillary wedge pressure, average pulmonary pressure, right atrial pressure and other indicators decreased. CONCLUSION: 5-Mononitro isosorbide ester injection is the same as isosorbide dinitrate injection and has a significant effect on congestive heart failure.