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OK-432/IL-2治疗60只C_(57),BL/6 小鼠体内移植性路易氏肺癌(Lewis lung cancer,LLC).实验结果如下:①治疗前15d中,Ⅲa、Ⅲb及Ⅳ组肿瘤直径始终小于Ⅰ、Ⅱ组,P<0.01,在>15d的治疗过程中,各组肿瘤直径趋于一致.②第15dⅠ、Ⅱ两组肿瘤重量明显大于 Ⅲa、Ⅲb及Ⅳ组,P<0、05.③Ⅰ、Ⅱ两组的肺转移瘤发生较Ⅲa、Ⅲb及Ⅳ组早,且前者转移灶数目较后者多,P<0.01.④15 d或 20 d,Ⅲa、Ⅲb及Ⅳ组的NK细胞活性及淋转刺激指数(SI)均高于 Ⅰ、Ⅱ组,P<0.01.
OK-432/IL-2 treatment of 60 C_(57), BL/6 mice transplanted Lewis lung cancer (LLC) in vivo. The experimental results are as follows: 1 15d before treatment, group IIIa, IIIb and IV The tumor diameter was always smaller than that of group I and II, P<0.01. In the course of treatment >15 days, the tumor diameters of all groups tend to be consistent.2 The tumor weights of the 15th day group I and II were significantly greater than those of group IIIa, IIIb, and IV, P<0. Pulmonary metastases in the 0, 5I, and II groups were earlier than those in the IIIa, IIIb, and IV groups, and the number of metastases in the former was higher than the latter, P<0.01.415d or 20d, and NK in the group IIIa, IIIb, and IV. The activity of cells and the index of SI were higher than those in groups I and II, P<0.01.