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目的 通过对一组急性HGV感染患者的肝组织病理和临床资料分析 ,探讨庚型肝炎病毒感染的致病性。方法 采用免疫组织化学技术对 5 9例不明原因急性肝炎患者的肝组织 ,进行乙、丙和庚型肝炎病毒抗原检测 ,部分病例经原位杂交证实。结果 HGVNS5抗原的检出率为 ( 5 7 6% ,3 4 /5 9) ,其中 2 0例肝组织中HBsAg和 /或HCVNS3Ag同时阳性 (HGV合并感染组 ) ,HGV阳性信号主要位于肝细胞浆内。HGV单纯感染病例与HGV重叠感染组相比 ,无论在病理改变或生化指标方面均无显著性差别。结论 HGV是一种嗜肝病毒 ,其感染可以引起急性病毒性肝炎
Objective To investigate the pathogenicity of hepatitis G virus infection by analyzing the histopathological and clinical data of a group of patients with acute HGV infection. Methods Immunohistochemical technique was used to detect hepatitis B, C and G hepatitis antigen in 59 cases of hepatitis with unexplained acute hepatitis, and some cases were confirmed by in situ hybridization. Results The positive rate of HGVNS5 antigen was (57.6%, 34/59), of which 20 cases of HBsAg and / or HCV NS3Ag were positive (HGV combined with infection), and the positive signals of HGV mainly located in hepatocyte cytoplasm Inside. HGV simple infection cases and HGV overlap infection group, no matter in terms of pathological changes or biochemical indicators were not significantly different. Conclusion HGV is a hepadnavirus whose infection can cause acute viral hepatitis