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目的：探究持续性雄激素阻断治疗即手术去势法（ surgical castration ）和间歇性雄激素阻断治疗（ intermittent androgen blockade， IAB）对晚期前列腺患者影响的差异。方法选取115例晚期前列腺癌患者，其中药物去势组48例，接受IAB治疗，手术去势组67例，接受手术去势治疗，在治疗前、治疗后第6个月、1年，采用生活质量调查表（ EORTC QLQ-C30总量表＋QLQ-PR25子量表）对2组患者进行总计3次生活质量调查。结果相比于治疗前，药物去势组和手术去势组患者的总体健康状况均明显提高（P＜0.01），全身和局部疼痛得到缓解（P＜0.01），排尿症状得到控制（P＜0.01）。药物去势组和手术去势组患者的总体生活质量均明显降低（P＜0.05），性功能受影响程度尤为严重（P＜0.01），但药物去势组患者在治疗后第1年，各项机体功能得到一定程度的恢复（P＜0.01），而手术去势组患者生活质量下降趋势在观察期间没有逆转。结论手术去势和药物去势治疗均会降低晚期前列腺癌患者的生活质量，但药物去势治疗对患者生活质量所造成的不利影响可在间歇期得到一定恢复。“,”Objective To explore the effects of surgical castration and intermittent androgen blockade (IAB) in patients with advanced prostate cancer.Methods 115 cases of advanced prostate cancer were selected including 48 cases with drug castration receiving IAB and 67 cases with surgical castration.Before the treatment, 6 months and 1 years after the treatment, the quality of life of the two groups was investigated by the quality of life questionnaire (EORTC QLQ-C30 +QLQ-PR25).Results Compared with before treatment, the general health status of the patients in the drug castration group and the surgical castration group were significantly improved (P<0.01), the whole body and the local pain were relieved (P<0.01) and the micturition symptoms were controlled ( P<0.01 ).The overall quality of life of drug castration group and surgical castration group were significantly decreased (P<0.05), and the degree of sexual function was particularly affected (P<0.01), but the body function of patients in drug castration group restored to a certain extent in drug castration group after 1 year’s treatment(P<0.01), while the quality of life in patients of surgical castration did not reverse.Conclusion Both of surgical castration and androgen deprivation therapy can reduce the quality of life of patients with advanced prostate cancer, but the adverse effects of drug treatment on the quality of life can be recovered in treatment intermission.