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复方丹参注射液是由丹参提取液和降香蒸馏液制成的每ml相当于生药各1g的灭菌水溶液。临床上用于治疗冠心病、心绞痛等症。注射中因含有丹参素、原儿茶醛等多种水溶性酚类化合物,性质不稳定,易被氧化从而导致成品色泽加深,含量下降。通常制备采用添加抗氧剂和溶液中充氮的方法来防止氧化,但产品的贮存期短、且色泽逐渐变深。我们经反复研究,采用多羟基化合物山梨醇和加入抗
Compound Salvia miltiorrhiza injection is a sterilized aqueous solution containing 1 g of crude drug per ml, which is prepared from the Salvia miltiorrhiza extract and the decocted distillate. Clinically used to treat coronary heart disease, angina and other embolism. Due to the presence of various water-soluble phenolic compounds such as Danshensu and protocatechuic aldehydes during injection, the properties are not stable, and they are easily oxidized, resulting in deepening of the finished product and lowering of the content. Usually prepared by the use of antioxidants and nitrogen in solution to prevent oxidation, but the product’s storage period is short, and the color gradually darkens. We have repeatedly studied using polyhydroxyl sorbitol and adding anti