Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain

• 作 者: Chunqiu Chen Jakub Fichna Mosh
• 机 构: ShanghaiTenthPeople’sHospital,DepartmentofBiomolecularChemistry,NeurimPharmaceuticalsLTD,DivisionofG
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2014年5期
• 关键词: GASTROINTESTINAL TRACT MELATONIN Neu-P11 Neu-P12 O Gastrointestinal tract Melat
• 基金项目: The University of Calgary Research Grant Committee(to Storr M),the Deutsche Forschungsgemeinschaft(STO 645/6-1 and 645/9-1 to Storr M),the Iuventus Plus program of the Polish Ministry of Science and H

AIM: To characterize the antinociceptive action of the novel melatonin receptor(MT) agonists, Neu-P11 and Neu-P12 in animal models of visceral pain. METHODS: Visceral pain was induced by intracolonic(ic) application of mustard oil or capsaicin solution or