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目的 :探讨用环孢素 A联合化疗方案治疗复发、难治性白血病的疗效。方法 :18例急性非淋巴细胞白血病患者 ,采用 Cs A+ DA方案治疗 6例 ,Cs A+ MAE方案治疗 12例。结果 :Cs A+DA组完全缓解率为 3 3 %。 Cs A+ MAE组完全缓解率为 5 0 %。两组病例的有效率及完全缓解率经统计学分析没有显著差异 ,P值均大于 0 .5。结论 :环孢素能够逆转难治性白血病的耐药性 ,在难治性白血病的治疗中有一定作用 ,但缓解后的治疗需要引起重视
Objective: To investigate the efficacy of cyclosporine A combined with chemotherapy in the treatment of relapsed and refractory leukemia. Methods : Eighteen patients with acute nonlymphocytic leukemia were treated with Cs A + DA regimen in 6 cases and Cs A + MAE regimen in 12 cases. Results : The complete response rate of Cs A+DA group was 3 3 %. The complete response rate was 50% in the Cs A+ MAE group. There was no significant difference between the two groups in the efficiency and complete remission rate by statistical analysis, P values were greater than 0.5. Conclusion: Cyclosporine can reverse the resistance of refractory leukemia and it has a certain role in the treatment of refractory leukemia, but the treatment after remission needs attention.