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回肠末段为胆酸再吸收的主要部位。切除回肠末段作旁路手术或回肠末段患病后,到达结肠的胆酸就增加。大量胆酸对结肠有致泻作用。近来有人认为某些病例的腹泻,是由于外源性微生物的毒索所致。因胆酪胺(Cholestyramine)能结合胆酸和内毒素,设想用它治疗难治性腹泻可能有效。作者报告7例严重的持续性腹泻患儿口服胆酪胺治疗有效。
The terminal ileum is the main part of bile acid reabsorption. Excision of the distal ileum for bypass surgery or the end of the ileum diseased, reaching the colon of bile acid increases. A large number of bile acid on the colon have caused diarrhea. Recently, some people think that some cases of diarrhea, due to the toxicity of exogenous microorganisms caused. Because cholestyramine binds to bile acids and endotoxins, it is envisaged that the treatment of refractory diarrhea may be effective. The authors report 7 cases of severe persistent diarrhea in children treated with bile tyramine effective.