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对134例无症状乙肝携带者母亲所生的新生儿，分A组（单纯疫苗组）；B组（乙肝疫苗和乙肝免疫球蛋白间隔免疫组）；C组（乙肝疫苗和乙肝免疫球蛋白同时免疫组）。根据母血又分单阳性和双阳性，进行实验观察，于免疫后12个月时检测抗－HBs，计算阳转率，双阳性A、B、C组分别为46.00％、96.42％、93．75％。单阳性分别为62．30％、92．30％、94．44％。阻断保护率双阳性分别为41．67％、95．53％、84．37％。单阳性分别为37．50％、71．15％、86．13％。经统计学处理，A组与B、C组有显著差异。而B、C组无明显差异，阻断效果相似，B、C组的明显优于A组。因此，应大力提倡乙肝疫苗和乙肝免疫球蛋白联合免疫措施。间隔或同时联合免疫均可采用。
Group A (simple vaccine group); Group B (hepatitis B vaccine and hepatitis B immunoglobulin interval immunization group); Group C (Hepatitis B vaccine and hepatitis B immunoglobulin simultaneously Immunization group). According to the maternal blood is divided into single positive and double positive, the experimental observation, 12 months after immunization detected anti-HBs, calculate the positive conversion rate, double positive A, B, C group were 46.00%, 96.42%, 93. 75%. Single positive were 62.30%, 92.30%, 94.44%. The positive rates of blocking protection were 41.67%, 95.53% and 84.37% respectively. Single positive were 37.50%, 71.15%, 86.13%. Statistically, A group and B, C group were significantly different. However, there was no significant difference between groups B and C, and the blocking effect was similar. The B and C groups were significantly better than the A group. Therefore, should be strongly advocated hepatitis B vaccine and hepatitis B immunoglobulin joint immunization measures. Interval or simultaneous immunization can be used.