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目的了解耐药结核病的危险因素。方法根据2000年结核病流行病学抽样调查个案数据库资料,选取性别、年龄、病例分类、地区、卫V项目5个因素进行单因素logistic回归分析。结果影响耐药的因素分析中,初治病例分类为耐药结核病的保护因素(OR=0.337,95%CI:0.222～0.512)。继发耐药影响因素分析中,45～59岁年龄组为继发耐药结核病的保护因素(OR=0.385,95%CI:0.201～0.738)。结论耐药、初始耐药、继发耐药的发生是多因素联合作用的结果,而非单一因素导致耐药,提示今后进行耐药结核病防治干预措施制定时,要考虑多种影响因素,制定综合防治措施,从而有效降低耐药结核病疫情。
Objective To understand the risk factors for drug-resistant TB. Methods According to the case database of epidemiological survey of tuberculosis in 2000, five factors including sex, age, case classification, region and health V were selected for univariate logistic regression analysis. Results In the analysis of the factors influencing drug resistance, newly diagnosed cases were classified as protective factors for drug-resistant TB (OR = 0.337, 95% CI: 0.222-0.512). In the analysis of influential factors of secondary drug resistance, the 45- to 59-year-old age group was the protective factor against secondary drug-resistant TB (OR = 0.385, 95% CI: 0.201-0.738). Conclusion The emergence of drug resistance, initial drug resistance and secondary drug resistance are the result of multifactorial combination, rather than the single factor leading to drug resistance, suggesting that in the future to develop drug-resistant tuberculosis prevention and treatment interventions, we should consider a variety of influencing factors and formulate Comprehensive prevention and control measures to effectively reduce the outbreak of drug-resistant TB.