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目的： 观察雌二醇（１７βｅｓｔｒａｄｉｏｌ，简称 Ｅ）对兔窦房结细胞动作电位的影响。方法：采用常规微电极技术记录兔窦房结细胞在不同 Ｅ浓度和作用时间的动作电位。结果：（１） Ｅ浓度依赖和时间依赖性显著延长窦房结细胞动作电位时程（ Ａ Ｐ Ｄ５０ 和 Ａ Ｐ Ｄ９０）及３ 期复极时间。（２） Ｅ浓度依赖和时间依赖性降低窦房结细胞动作电位０ 期最大除极速率（ Ｖｍ ａｘ）、动作电位幅度（ Ａ Ｐ Ａ）和延长０ 期除极时间，且 Ｅ１×１０５ｍ ｏｌ／ Ｌ组观察到８０～１００ ｍ ｉｎ 时，有３例动作电位完全消失。结论： Ｅ对窦房结细胞 Ｋ＋ 通道和 Ｃａ２＋ 通道都有阻断作用。
Objective: To observe the effect of 17β-estradiol (E) on the action potentials of rabbit sinoatrial node cells. Methods: The action potentials of rabbit sinoatrial node cells at different E concentrations and time were recorded by conventional microelectrode technique. Results: (1) E concentration-dependent and time-dependent significantly prolongs the action potential duration of sinoatrial node cells (A P D50 and A P D90) and phase 3 repolarization time. (2) E concentration-dependent and time-dependent decrease of maximal depolarization rate (Vm ax), action potential amplitude (A P A) and prolongation of depolarization time of stage 0 of sinus node cell action potential 0, and E1 × 10 -5m In the ol / L group, the action potentials disappeared completely in 80-100 mins. Conclusion: E can block the K + channels and Ca2 + channels of sinoatrial node cells.