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从机体糖代谢角度初步探索偏二甲基肼急性中毒的生化机理，采用紫外分光光度法实验检测了大鼠血中丙酮酸、α－酮戍二酸的含量。实验结果显示：偏二甲基肼染毒后，大鼠血中丙酮酸含量降低，特别是染毒６０ｍｉｎ和９０ｍｉｎ时，各剂量组丙酮酸含量显著地降低（ｐ＜０．０１）；各剂量组α－酮戍二酸含量亦明显降低，且存在一定的量效和时效关系。这些结果提示，偏二甲基肼可影响机体糖代谢，干扰糖的有氧氧化过程，继而引起能量代谢障碍，导致中枢神经系统中毒。
From the perspective of the body sugar metabolism to explore the biochemical mechanism of acute exposure to dimethylhydrazine, UV spectrophotometry was used to test the content of pyruvate and α-ketobutyric acid in rat blood. The experimental results showed that pyruvate decreased in the blood of rats after exposure to PDMS, especially at 60 and 90 min (P <0.01) Group α-ketose glutaric acid content also significantly reduced, and there is a certain amount of effect and the relationship between aging. These results suggest that partial dimethyl hydrazine can affect the body’s sugar metabolism, interfering with the carbohydrate oxygen oxidation process, which in turn cause energy metabolism disorders, leading to central nervous system poisoning.