Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in

• 作 者: Waqar Khalid Saeed Dae Won Jun
• 机 构: DepartmentofGastroenterology,DepartmentofPathology,DepartmentofInternalMedicine,DepartmentofTranslat
• 出 处: 世界胃肠病学杂志:英文版
• 发表日期: 2018年48期
• 关键词: NECROPTOSIS RECEPTOR interacting PROTEIN kinase-3 Mixed LINEAGE kinase domain-li
• 基金项目: National Research Foundation of Korea(NRF),funded by the South Korean Government,No.NRF-2017M3A9C8028794.

AIM To validate the effects of receptor interacting protein kinase-3(RIP3)deletion in non-alcoholic fatty liver disease(NAFLD)and to clarify the mechanism of action.METHODS Wild-type(WT)and RIP3 knockout(KO)mice were fed normal chow and high fat(HF)diets