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目的探讨白介素-8(IL-8)对慢性阻塞性肺疾病(COPD)病程的影响及血清IL-8检测在监测COPD急性加重期(AECOPD)使用糖皮质激素(以下简称激素)治疗中炎症控制的临床应用价值。方法对经肺功能检测确诊为COPD的急性加重期中度35例患者给予抗感染等常规治疗及激素治疗前、后及36例健康成人的外周血测定IL-8及血白细胞(WBC)。结果病例组血清IL-8及血WBC使用激素等治疗前、后有显著性差异(P<0.05);治疗后与健康对照组比较也有显著性差别(P<0.05),但使用激素治疗后WBC是升高的。结论IL-8不仅参与COPD的急性炎症过程,在症状缓解的平稳期的患者中也有明显增高,提示它参与了COPD病程的进展,是气道炎症不可逆转的原因之一;血清IL-8可作为观察AECOPD使用激素治疗中炎症控制的敏感指标。
Objective To investigate the effect of interleukin-8 (IL-8) on the course of chronic obstructive pulmonary disease (COPD) and the level of serum IL-8 in the monitoring of inflammation in the treatment of acute exacerbation of COPD (AECOPD) with glucocorticoid The clinical value. Methods Thirty-five patients with moderate exacerbations diagnosed as COPD by pulmonary function test were given anti-infective and other routine therapy before and after hormone therapy and peripheral blood from 36 healthy adults for determination of IL-8 and white blood cell (WBC). Results The levels of IL-8 and WBC in the patients before and after treatment were significantly different (P <0.05), but there was also a significant difference between the two groups after treatment (P <0.05) Is elevated. Conclusion IL-8 is not only involved in the acute inflammatory process of COPD, but also significantly increased in patients with stable symptoms, suggesting that IL-8 is involved in the progression of COPD and is one of the causes of irreversible airway inflammation. IL-8 As a sensitive indicator of the use of hormonal therapy in AECOPD to control inflammation.