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(下简称KM),是从一株放线菌4281号菌丝中分离到的复合物,属于蒽环类的抗肿瘤抗菌素,但它和所有已知的蒽环类抗肿瘤抗菌素又有所区别。产生菌的分离和鉴别:产生菌4281号是将土壤悬液接种到含有链霉素的特定培养基中分离而得,在琼脂中对革兰氏阳性细菌有抑制作用,对大肠杆菌也有微弱作用;从菌丝中分离的抗菌素,经证明属于蒽环类化合物,具有抗肿瘤作用。 4281号的气生菌丝白色至玫瑰色,孢子链短,呈单轴排列,孢子链通常卷曲成圈或
(Hereinafter referred to as KM) is a compound isolated from mycelium of an actinomycete 4281 and belongs to anthracycline antitumor antibiotic, but it differs from all known anthracycline antitumor antibiotics . Isolation and identification of producing bacteria: producing bacteria No. 4281 is inoculated into a suspension of soil streptomycin-containing specific medium derived from Agar in Gram-positive bacteria have an inhibitory effect on Escherichia coli has a weak effect Antibiotics isolated from mycelium proved to be anthracyclines and have anti-tumor effects. 4281 aerial mycelium white to rose, spore chain is short, uniaxial arrangement, the spore chain is usually curled into a circle or