The endogenous negative regulators:potential drug target for treatment of septic shock

• 出 处: 中国病理生理杂志
• 发表日期: 2012年11期
• 关键词: septic hypotension sepsis Transcription endogenous cardiovascular microbial Bact

Bacteria-induced sepsis and septic shock is characterized by cardiovascular collapse following microbial invasion of the body.The progressive hypotension,hyporeactivity to vasopressor agents and vascular leak lead to circulatory failure with multiple organ dysfunction and death.Transcription factor NF-κB and inflammatory cytokines(e.g.TNF-αand IL-1β)play critical roles in the

Bacteria-induced sepsis and septic shock is characterized by cardiovascular collapse following microbial invasion of the body. The progressive hypotension, hyporeactivity to vasopressor agents and vascular leak lead to circulatory failure with multiple organ dysfunction and death. Transcription factor NF-κB and inflammatory cytokines egTNF-αand IL-1β) play critical roles in the