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目的 了解系统性红斑狼疮 (SL E)患者外周血循环内皮细胞 (CEC)的数量及其临床意义。方法 采用密度梯度离心法检测 45例 SLE患者和 30例正常人的血液标本。结果 SL E患者和正常人的 CEC数量分别是 (7.8± 4.2 )× 10 6 /L、(3.7± 1.1)×10 6 /L,两者之间的差异有高度显著性 (P<0 .0 1) ;活动期患者的 CEC数量高于非活动期患者 (P<0 .0 1) ;SLE患者 CEC数量与病情积分呈正相关 (r=0 .3817,P<0 .0 5 )。结论 SL E患者的 CEC数量升高 ,测定 CEC数量对判断 SL E患者的病情活动程度有帮助。
Objective To investigate the quantity and clinical significance of circulating endothelial cells (CECs) in patients with systemic lupus erythematosus (SL E). Methods Blood samples were collected from 45 SLE patients and 30 healthy controls by density gradient centrifugation. Results The number of CECs in patients with SL E and normal controls were (7.8 ± 4.2) × 10 6 / L and (3.7 ± 1.1) × 10 6 / L, respectively. There was a significant difference between the two groups (P <0. 0 1). The number of CECs in active patients was higher than inactive patients (P <0.01). The number of CECs in patients with SLE was positively correlated with disease scores (r = 0.3817, P <0.05). Conclusion The number of CECs in patients with SLE is increased. The determination of the number of CECs is helpful in judging the severity of SLE.