新型冠状病毒肺炎临床诊治及质谱组学研究进展

来源 :分析试验室 | 被引量 : 0次 | 上传用户：pan2009pan

【摘要】

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【作者】

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王天宇刘京净胡龙龙罗夏琳吕海涛

【机构】

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上海交通大学系统生物医学教育部重点实验室,功能代谢组科学实验和系统生物医学研究院,上海200240

【出处】

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分析试验室

【发表日期】

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2021年10期

【关键词】

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新型冠状病毒肺炎大流行病质谱生命组学分子诊断治疗发现

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新型冠状病毒肺炎(COVID-19)是由严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)引发的一种呼吸系统传染性疾病,自2019年末爆发以来,在全球范围内迅速蔓延.该传染性疾病是本世纪以来全球遭遇的感染范围最广、防控难度最大的重大突发公共卫生事件,其对人类健康和社会经济发展造成严重影响.全球多个实验室针对SARS-CoV-2开发了一系列检测方法,包括分子生物学方法和血清学检测方法等.近年来,高分辨质谱分析技术的飞速发展,其驱动的多组学方法策略已经被广泛应用于各类传染性疾病的精准诊断、病原序列测定以及药物靶点发掘等研究.基于此,本文对新冠肺炎的发病机理、诊断方法、预防手段和治疗策略进行简要归纳总结,重点聚焦于基于质谱的组学技术在新型冠状病毒肺炎诊疗过程中的应用实践研究,包括分子诊断、病源机理解析和药物开发等,以期为COVID-19的诊疗和防控提供新的思路和方法借鉴.

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新型冠状病毒肺炎临床诊治及质谱组学研究进展

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