论文部分内容阅读
右心室肥厚（right ventricular hypertrophy, RVH）和右心室衰竭（right ventricular failure, RVF）是具有致命性的恶性心脏疾病，肺动脉高压（pulmonary arterial hypertension, PAH）是主要的致病因素。大量研究已经发现，Can 2+处理重塑在RVH和RVF发展过程中起至关重要的作用。文章主要以心力衰竭（heart failure, HF）患者的两大主要死因（心脏泵血功能下降和恶性心律失常）为框架，从微观角度详细阐述了在RVH和RVF病理过程中Can 2+的作用及Can 2+稳态的变化，以期为临床诊断与治疗提供新的方向。n “,”Right ventricular hypertrophy (RVH) and right ventricular failure (RVF) are fatal heart disease. Pulmonary arterial hypertension (PAH) is the main pathogenic factor. Numerous studies have found that Can 2+ handling remodeling plays a vital role in the progression of RVH and RVF. Using the heart failure (HF)\'s two major causes of death (attenuation of myocardial pump function and malignant arrhythmia) as a frame, this review summarizes the role of Can 2+ and Can 2+ homeostasis alteration in pathological process of RVH and RVF from the micro aspects aims to provide a new direction for clinical diagnosis and treatment.n