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[目的]探究NGAL通路关键因子与溃疡性结肠炎复发的相关性研究及临床应用。[方法]随机收集我院收治的89例溃疡性结肠炎患者,根据其严重程度分为轻、中度UC组与重度UC组,分别检测患者体内的NGAL通路关键因子水平,并对比分析两组患者治疗缓解后的复发情况。[结果]治疗前重度UC组患者的血清NGAL水平明显高于轻、中度UC组患者,差异有统计学意义(P<0.05)。治疗后重度UC组患者的血清NGAL水平与轻、中度UC组患者相比未见明显差异(P>0.05)。治疗缓解患者重度UC组停药后3个月、停药后6个月的复发率明显高轻、中度UC组患者,差异有统计学意义(P<0.05)。[结论]NGAL水平在溃疡性结肠炎患者中明显升高,且疾病活动程度越高,其NGAL水平升高越明显,患者的复发率也随之升高,控制患者NGAL水平,有利于预防疾病复发,具有重要临床意义。
[Objective] To investigate the correlation between the key factors of NGAL pathway and the recurrence of ulcerative colitis and its clinical application. [Methods] A total of 89 patients with ulcerative colitis who were admitted to our hospital were randomly divided into mild and moderate UC group and severe UC group according to their severity. The level of key factors of NGAL pathway in the patients were detected, Patient remission after treatment of remission. [Results] The level of serum NGAL in patients with severe UC before treatment was significantly higher than that in patients with mild to moderate UC (P <0.05). There was no significant difference in serum NGAL levels between severe UC patients and mild and moderate UC patients after treatment (P> 0.05). Treatment remission patients with severe UC 3 months after discontinuation of the drug, 6 months after stopping the recurrence rate was significantly higher in patients with moderate UC, the difference was statistically significant (P <0.05). [Conclusion] The level of NGAL in patients with ulcerative colitis was significantly higher, and the higher the degree of disease activity, the more obvious the level of NGAL increased, and the relapse rate of patients also increased. Control of NGAL level in patients was helpful to prevent diseases Recurrence, has important clinical significance.