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目的:探讨5-HTT基因连锁多态区(5-HTTLPR)多态性以及环境因素对发生产后抑郁的影响。方法:从武汉大学中南医院随机收集240例产妇(2012年4月至2013年4月),通过爱丁堡产后抑郁量表(EPDS)评分,诊断出39例产后抑郁患者作为观察组,再按照随机抽样的方法从剩下的产妇中抽取39例作为对照组,运用聚合酶链反应技术(PCR)检测两组5-HTTLPR多态性的基因(S和L)和基因型(SS、SL、LL)的分布频率;再对两者之间环境因素进行比较。结果:观察组5-HTTLPR短重复序列/短重复序列(short/short,S/S)基因型和短重复序列(short,S)频率分别为71.8%、83.3%,明显的高于对照组(43.5%、57.5%),两组之间的差异具有统计学意义(P<0.05);环境因素中丈夫的体贴程度、期待胎儿性别、婆媳关系、夫妻关系因素在两者之间的差异具有统计学意义。结论:5-HTTLPR的SS基因型可能是产后抑郁症的易感基因之一,而环境因素是产后抑郁症发病的重要因素。
Objective: To investigate the polymorphisms of 5-HTT gene polymorphism (5-HTTLPR) and the influence of environmental factors on postpartum depression. Methods: A total of 240 maternal women (from April 2012 to April 2013) were randomly collected from Zhongnan Hospital of Wuhan University. According to the EPDS score, 39 postpartum depression patients were diagnosed as observation group and randomly selected according to random sampling (39 cases) were selected as the control group. The genotypes (SS, SL, LL) of 5-HTTLPR polymorphism and genotypes were detected by polymerase chain reaction (PCR) The frequency of distribution; and then compare the environmental factors between the two. Results: The frequencies of 5-HTTLPR short / short (S / S) genotypes and short, S repeats were 71.8% and 83.3% in the observation group, which were significantly higher than those in the control group 43.5% and 57.5%, respectively). The difference between the two groups was statistically significant (P <0.05). The difference between husband and wife in environmental factors, the expectation of fetal sex, the relationship between mother-in-law and wife and husband was statistically significant Significance of learning. Conclusion: The SS genotype of 5-HTTLPR may be one of the predisposing genes for postpartum depression, and environmental factors are the important factors of postpartum depression.