论文部分内容阅读
高脂血症是60岁以下男性发生脑梗塞的危险因素,其 HDL-ch 多持续降低,近来又发现脑梗塞患者 HDL-ch 中的前脂蛋白 E(apo E)浓度亦降低。apoE 是由229个氨基酸所组成的多肽,具遗传多型性的特征,它由遗传基因∑2、∑3和∑4组成为 E2/2、E3/2、E3/3、E4/2、E4/3和 E4/46个表型。日本人与德、美人相比,E3/3较多,而 E3/2则较少。目前对冠状动脉疾病患者的表型研究较多,而脑梗塞研究甚少,为此作者对50例无缺血性心脏病,无内分泌或代谢性疾病及未服可影响血脂的药物且发病已2年的脑
Hyperlipidemia is a risk factor for cerebral infarction in men under the age of 60 with a continuous decrease in HDL-ch. Recently, it has also been found that the concentration of pro-ApoE in HDL-ch is also decreased in patients with cerebral infarction. ApoE is a polypeptide consisting of 229 amino acids, which is characterized by genetic polymorphism. It consists of E2, 2, E3 / 3, E4 / 2 and E4 / 3 and E4 / 46 phenotypes. Japanese compared with German and American, E3 / 3 is more, while E3 / 2 is less. At present, there are more phenotypes in patients with coronary artery disease, and little research on cerebral infarction. To this end, the author of 50 patients without ischemic heart disease, no endocrine or metabolic diseases and not taking blood lipids can affect the drug has been 2 years brain