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目的研究血管内皮生长因子(CVEGF-C)在食管鳞癌中的表达及其与肿瘤淋巴转移和预后的关系。方法运用免疫组化方法检测VEGF-C在72例食管鳞癌组织及其相应正常食管粘膜组织中的表达,经计算机图像分析,计算免疫组化阳性细胞百分率。结果正常食管粘膜中未见VEGF-C抗原的表达,而在72例食管鳞癌组织中有28例阳性表达(38.9%)。VEGF-C抗原表达与肿瘤的浸润深度和淋巴结转移密切相关(χ2=10.77,P<0.01;χ2=10.98,P<0.01),但与患者的年龄、肿瘤的大小及分化程度无关。VEGF-C阳性组患者的生存率显著低于VEGF-C阴性组(χ2=11.16,P<0.01)。结论VEGF-C的表达可促进食管鳞癌的淋巴转移。VEGF-C抗原可作为判断食管鳞癌不良预后的危险因子。
Objective To investigate the expression of vascular endothelial growth factor (CVEGF-C) in esophageal squamous cell carcinoma and its relationship with lymph node metastasis and prognosis. Methods The expression of VEGF-C in 72 cases of esophageal squamous cell carcinoma and its corresponding normal esophageal mucosa was detected by immunohistochemistry. The percentage of positive cells in the immunohistochemistry was calculated by computer image analysis. Results The expression of VEGF-C antigen was not found in normal esophageal mucosa, while 28 of 72 esophageal squamous cell carcinomas were positive (38.9%). The expression of VEGF-C was closely related to the depth of invasion and lymph node metastasis (χ2 = 10.77, P <0.01; χ2 = 10.98, P <0.01), but not with age, tumor size and differentiation. The survival rate of patients with VEGF-C positive was significantly lower than that of VEGF-C negative (χ2 = 11.16, P <0.01). Conclusion The expression of VEGF-C can promote the lymphatic metastasis of esophageal squamous cell carcinoma. VEGF-C antigen can be used as a risk factor to determine the poor prognosis of esophageal squamous cell carcinoma.