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[目的]观察重组人干扰素α-2b凝胶配合激光治疗宫颈上皮内瘤变Ⅰ级(CINⅠ)的临床效果。[方法]将CINⅠ合并宫颈糜烂患者随机分为两组,观察组49例于月经干净3d予单纯激光治疗。对照组47例则于月经干净3d予激光治疗及治疗后再以尤靖安(重组人干扰素α-2b凝胶)lg阴道给药,隔日1次,共10次(月经期停用)为一疗程。两组均于治疗后2个月(月经期干净后3～7d)随访治疗后宫颈糜烂好转情况。6个月随访宫颈细胞学情况。[结果]纳入疗效分析82例(观察组40例,对照组42例),治疗2月后两组有效率比较,对照组高于观察组,差异有统计学意义(P﹤0.05);6个月随访复发率明显低于观察组,差异有统计学意义(P﹤0.05)。[结论]重组人干扰素α-2b凝胶配合激光治疗CINⅠ比单纯激光治疗治愈率高,复发率低,且术后宫颈糜烂恢复情况也较单纯激光组好,值得临床推广。
[Objective] To observe the clinical effect of recombinant human interferon α-2b gel combined with laser treatment of cervical intraepithelial neoplasia grade Ⅰ (CIN Ⅰ). [Methods] Patients with cervical erosion of CIN Ⅰ were randomly divided into two groups. 49 cases in the observation group were treated with simple laser treatment on the clean days of menstruation. In the control group, 47 cases were treated with vaginal administration of Yijing (recombinant human interferon α-2b gel) lg once a month for 10 times (menstrual phase was disabled) A course of treatment. Both groups were treated 2 months after treatment (menstrual clean 3 ~ 7d) follow-up treatment of cervical erosion improved situation. 6-month follow-up of cervical cytology. [Results] 82 cases (observation group 40 cases, control group 42 cases) were included in the curative effect analysis. After two months of treatment, the effective rates of the two groups were significantly higher than those of the observation group (P <0.05) The follow-up recurrence rate was significantly lower than the observation group, the difference was statistically significant (P <0.05). [Conclusion] Recombinant human interferon α-2b gel with laser treatment of CIN Ⅰ than simple laser cure rate, recurrence rate is low, and postoperative recovery of cervical erosion than the simple laser group, worthy of clinical promotion.