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目的分析新生儿血培养阳性标本中各病原菌分布情况及与hs-CRP的相关性。方法统计分析2015年1月至2016年1月大连市妇幼保健院新生儿ICU血培养临床资料并采用CRP检测试剂盒对血培养阳性的患者进行hs-CRP的检测。结果血培养阳性结果中,凝固酶阴性葡萄球菌46株,占65.7%,肺炎克雷伯菌8株,占11.4%,大肠埃希菌5株,占7.1%,肠杆菌、鲍曼不动杆菌、洛非不动杆菌各2株,分别占2.9%,摩根摩根菌、B群链球菌、金黄色葡萄球菌、肠球菌、微球菌各1株,分别占1.4%;hs-CRP的检出量,革兰阴性菌感染组为(20.60±3.40)mg/L,革兰阳性菌感染组为(15.80±2.30)mg/L,正常对照组为(4.10±0.95)mg/L。结论新生儿血培养阳性的主要致病菌为凝固酶阴性葡萄球菌、肺炎克雷伯菌和大肠埃希菌;有细菌感染的新生儿血中hs-CRP值升高,革兰阴性菌感染hs-CRP值高于革兰阳性菌。
Objective To analyze the distribution of pathogens in positive samples of neonatal blood culture and its correlation with hs-CRP. Methods The clinical data of neonatal ICU blood culture in MCH from January 2015 to January 2016 were statistically analyzed. The CRP detection kit was used to detect hs-CRP in blood culture-positive patients. Results Among the positive results of blood culture, 46 strains of coagulase-negative staphylococci (65.7%), 8 strains of Klebsiella pneumoniae (11.4%) and 5 strains of Escherichia coli (7.1%) were positive for Enterobacteriaceae and Acinetobacter baumannii , Two strains of Acinetobacter baumannii each accounted for 2.9%, and one strain of Morganella morganii, Group B streptococcus, Staphylococcus aureus, Enterococcus and Micrococci each accounted for 1.4% respectively; the detection of hs-CRP (20.60 ± 3.40) mg / L in Gram-negative bacteria group, (15.80 ± 2.30) mg / L in Gram-positive bacteria group and (4.10 ± 0.95) mg / L in normal control group. Conclusions The main pathogens positive for blood culture in neonates are coagulase-negative Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli. The serum hs-CRP level in neonates with bacterial infection is elevated, and the gram-negative bacteria are infected with hs -CRP value higher than gram-positive bacteria.