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探讨PCNA、P~(53)的过度表达与喉癌预后的关系。方法：应用免疫组化ABC法对56例喉鳞癌和7例喉正常组织检测。结果：56例喉癌中，PCNA、P~(53)阳性率分别为71．4％和51．8％。正常组织染色阴性。喉癌的临床分期、有无淋巴结转移和患者术后3年生存率与PCNA、P~(53)阳性表达率关系密切。结论：PCNA、P~(53)的过度表达与喉癌的不良预后有关。
To investigate the relationship between the over-expression of PCNA and P ~ (53) and the prognosis of laryngeal carcinoma. Methods: Immunohistochemical ABC method was used to detect 56 cases of laryngeal squamous cell carcinoma and 7 cases of laryngeal squamous cell carcinoma. Results: The positive rates of PCNA and P53 in 56 cases of laryngeal carcinoma were 71.4% and 51.8% respectively. Normal tissue staining negative. The clinical stage of laryngeal cancer, with or without lymph node metastasis, and 3-year postoperative survival rate were closely related to the positive rate of PCNA and p53. Conclusion: The overexpression of PCNA and P53 is associated with the poor prognosis of laryngeal cancer.