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目的:回顾性分析总结影响子宫内膜癌预后的高危因素。方法:对2000年12月~2004年12月中山大学附属第三医院、中山大学附属第二医院及中山大学附属肿瘤医院妇科收治的189例子宫内膜癌病例进行回顾性分析,进一步探讨病理类型、组织学分级、肌层浸润深度、淋巴结转移、手术病理分期、合并症与预后之间的关系。结果:手术病理分期、不同病理类型、组织学分级、有无肌层浸润和淋巴结转移中患者的生存曲线比较,结果均P<0.05,差异有统计学业意义;有无合并糖尿病、高血压或肥胖患者的生存曲线比较,结果均P>0.05,差异无统计学意义。COX回归多因素分析,组织学分级与肌层浸润深度对生存时间的影响差异有统计学意义(P<0.05)。结论:特殊病理类型、组织学低分化、深肌层浸润、淋巴结转移、期别晚是提示预后不良的高危因素。
Objective: To retrospectively analyze the high risk factors that influence the prognosis of endometrial carcinoma. Methods: A retrospective analysis of 189 cases of endometrial cancer admitted to the Third Affiliated Hospital of Sun Yat-sen University, the Second Affiliated Hospital of Sun Yat-sen University and the Affiliated Tumor Hospital of Sun Yat-sen University from December 2000 to December 2004 was conducted to further investigate the pathological types , Histological grade, depth of myometrial invasion, lymph node metastasis, surgical pathology, complications and prognosis. Results: The survival curves of patients with pathological staging, different pathological types, histological grade, with or without myometrial invasion and lymph node metastasis were compared, the results were statistically significant (P <0.05); with or without diabetes mellitus, hypertension or obesity The survival curves of patients, the results were P> 0.05, the difference was not statistically significant. COX regression multivariate analysis, histological grade and depth of myometrial invasion of survival time difference was statistically significant (P <0.05). Conclusion: The special pathological types, poorly differentiated histology, deep myometrial invasion, lymph node metastasis, late-stage prognosis are risk factors for poor prognosis.