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米非司酮(RU486)结合前列腺素类似物能成功地终止妊娠。标准的给药方案是口服RU486后36～48h再应用前列腺素类似物。使用比较普遍的两种前列腺素类似物是硫酸噻普酮(sulprostone)和吉美前列素(geme-prost)。硫酸噻普酮为肌肉注射,一直是欧洲人更喜欢选择的前列腺素,但自出现3例心肌梗塞后,最近从市场上退出。吉美前列素为阴道内给药,应用安全,但价格昂贵且需特殊
Mifepristone (RU486) in combination with prostaglandin analogues can successfully terminate the pregnancy. The standard dosing regimen is the use of prostaglandin analogues 36 to 48 hours after RU486 administration. Two prostaglandin analogues that are commonly used are sulprostone and geme-prost. Sulpredone sulfate, administered intramuscularly, has been a prostaglandin that Europeans prefer to choose from, but has recently withdrawn from the market since the emergence of three myocardial infarctions. Gemcitabine is administered intravaginally and safely, but it is expensive and special