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糖原合酶激酶-3(GSK3)是一种多功能的丝氨酸/苏氨酸激酶,被不同的刺激启动,作用于众多的信号通路,在许多生理过程中起到了核心的作用,这包括转录、细胞周期的区分、细胞凋亡、细胞的结局和干细胞的维持等。其中有几条通路和疾病的发生关系密切,这预示着GSK3特异性抑制剂可用于
Glycogen synthase kinase-3 (GSK3), a multifunctional serine / threonine kinase, is activated by a variety of stimuli and acts on numerous signaling pathways and plays a central role in many physiological processes including transcription Differentiation of cell cycle, apoptosis, cell outcome and stem cell maintenance. Several of these pathways are closely linked to disease progression, suggesting that GSK3-specific inhibitors may be used