论文部分内容阅读
目的评价在本生殖中心开展体外受精-胚胎移植技术(IVF-ET)的安全性和有效性,探讨影响IVF-ET治疗结局的因素。方法总结分析2002年11月至2005年12月在本中心完成的156个IVF-ET周期病历资料。结果完成移植144周期,平均每周期使用果纳芬(29．75±9．01) 支,获卵10．41个,受精率79．12％,卵裂率93．00％,优质胚胎率51．04％,周期临床妊娠率36．81％, 流产率16．98％,异位妊娠率3．77％,多胎率18．87％,中、重度卵巢过度刺激综合征发生率3．85％。年龄≥35岁患者临床妊娠率、获卵率、胚胎冷冻率均低于年龄<35岁患者,周期取消率高于年龄<35 岁患者。有输卵管、卵巢手术史者卵巢低反应发生率增加。结论本中心开展IVF-ET技术是安全和有效的。年龄过大、窦卵泡数过少以及有盆腔手术史等均是影响IVF-ET治疗成功率的因素。
Objective To evaluate the safety and efficacy of in vitro fertilization-embryo transfer (IVF-ET) in this reproductive center and to explore the factors influencing the outcome of IVF-ET. Methods The data of 156 IVF-ET cycles recorded in our center from November 2002 to December 2005 were summarized and analyzed. RESULTS: 144 cycles of transplantation were completed. The average number of cycles per week was 29.75 ± 9.01 with 10.41 eggs, fertilization rate of 79.12%, cleavage rate of 93.00% and quality embryo rate of 51 .04%. The clinical pregnancy rate was 36.81%, the miscarriage rate was 16.98%, the ectopic pregnancy rate was 3.77%, the multiple pregnancy rate was 18.87%. The incidence of moderate and severe ovarian hyperstimulation syndrome was 3.85% . The clinical pregnancy rate, ovulation rate and embryo freezing rate of patients aged 35 years or older were lower than those of patients <35 years old, and the cycle cancellation rate was higher than those of patients <35 years of age. With tubal, ovarian surgery history of ovarian low response rate increased. Conclusion The Center for IVF-ET technology is safe and effective. Age is too large, the number of antral follicles is too small, as well as a history of pelvic surgery are the factors that affect the success rate of IVF-ET treatment.