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目的 探究单唾液酸四己糖神经节苷脂钠注射液对脑出血患者神经功能恢复疗效并初探其作用机制.方法 本探究研究对象为2014年8月-2016年8月于焦作市人民医院治疗的100例脑出血患者,对其病历资料进行回顾性分析,将采用脱水、利尿、降颅内压、控制血糖、血压等常规治疗的48例患者设为对照组,在常规治疗基础上加用单唾液酸四己糖神经节苷脂钠注射液治疗的52例患者设为观察组.两组患者连续治疗两周后进行疗效比较,采用神经功能缺损(NIHSS)评分评价治疗前后神经功能,采用Barthel指数评价生活能力,并详细记录两组患者治疗前后动脉收缩压、舒张压变化.结果 观察组治疗总有效率为90.38％,显著高于对照组(79.17％),有统计学意义(P＜0.05);两组治疗前NIHSS、Banhel指数无显著性差异(P＞0.05),治疗后与治疗前差异显著,且治疗后组间比较差异显著,有统计学意义(P＜0.05);两组治疗前动脉收缩压、舒张压无显著性差异(P＞0.05),治疗后均显著降低,且治疗后观察组显著低于对照组,有统计学意义(P＜0.05).结论 相较于常规治疗,单唾液酸四己糖神经节苷脂钠注射液对脑出血患者神经功能恢复效果更佳,降血压效果更优,这可能与其神经保护机制有关.“,”Objective To explore the curative effect and mechanism of monosialo four hexose ganglioside sodium injection on neurological function recovery in patients with cerebral hemorrhage.Methods The research object was 100 cases of cerebral hemorrhage patients in our hospital from August 2014 to August 2016,the medical data was retrospectively analyzed,48 cases received conventional treatment like dehydration,diuresis,intracranial pressure decreasing,blood glucose control,blood pressure were set as the control group,52 cases took monosialo four hexose ganglioside sodium injection on the basis of conventional therapy were set as the observation group.Effect of two groups was compared after two weeks of continuous treatment,the neurological deficit (NIHSS) score was used to evaluate neurological function before and after treatment,evaluation of the life ability was taken by Barthel index,and detailed records of the two groups before and after treatment of systolic arterial pressure,diastolic pressure changes were made.Results The total efficiency rate of the observation group was 90.38％,which was significantly higher than that of the control group (79.17％),showing statistical significance (P ＜ 0.05);The two groups' preoperative NIHSS,Barthel index had no significant difference (P ＞ 0.05),data after treatment had significant difference with that before treatment,and after treatment,the difference between groups was significant,showing statistical significance (P ＜ 0.05);The two groups' before treatment intracranial pressure,systolic arterial pressure,diastolic pressure had no significant difference (P ＞ 0.05),data was significantly decreased after treatment,and that of the observation group after treatment was significantly lower than that of the control group,there was statistical significance (P ＜ 0.05).Conclusion Compared with conventional treatment,monosialo four hexose ganglioside sodium injection shows better effect on neurological function recovery in patients with cerebral hemorrhage,also does well in decreasing blood pressure,intracranial pressure,which may be related to its mechanism of neuroprotection.