Improvement of Thioester Method by Using Pac Ester for Synthesis of Cyclopentapeptides

• 出 处: Chinese Chemical Letters
• 发表日期: 2002年11期
• 关键词: protected constants cyclization elongation resin acetic reagent removed facility

Thioester method was improved by using Pac (phenacyl group) ester as protecting group of 3-mercaptopropionic acid. Two cyclopentapeptides c(Ala-Tyr-Leu-Ala-Gly) and c(Pro-Tyr-Leu- Ala-Gly) were synthesized successfully by this method.

Thioester method was improved by using Pac (phenacyl group) ester as protecting group of 3-mercaptopropionic acid. Two cyclopentapeptides c (Ala-Tyr-Leu-Ala-Gly) and c (Pro- Tyr-Leu- Ala- Gly) successfully by this method.