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暴露于有机锡化合物的动物可产生一系列神经系统症状,脑生物胺水平降低,肝脏的药物氧化作用及c-AMP的代谢亦可受影响。因此,作者对氧化二辛基锡(DOTO)、羟化三环己烷基锡(TCHTOH)和氧化三丁基锡(TBTO)对大鼠肝、肾中某些酶的活性及脑中生物胺水平的影响进行了细致研究。实验用6个月雄性Wistar大鼠24只,分为4组。将有机锡化合物溶于花生油中,第Ⅰ、Ⅱ、Ⅲ组动物分别注射DOTO,TBTO,TCHTOH油剂(25μmol锡/0.5
Animals exposed to organotin compounds can develop a range of neurological symptoms, reduced levels of biogenic amines, liver drug oxidation, and c-AMP metabolism. Therefore, the authors investigated the effects of dioctyltin (TOTO), TCHTOH and TBTO on the activity of some enzymes in liver and kidney and the levels of biogenic amines in the brain A detailed study. Twenty-four male Wistar rats aged 6 months were divided into 4 groups. The organotin compounds were dissolved in peanut oil, the animals in groups Ⅰ, Ⅱ and Ⅲ were injected with DOTO, TBTO and TCHTOH oil (25μmol tin / 0.5