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目的 探讨多层螺旋CT(MSCT)肺密度测定对结缔组织病(CTD)肺间质病变(ILL)早期诊断的临床意义。方法 对2 2 2例CTD患者及5 0名正常对照者,应用MSCT附带的Pulmo自动评估软件进行上、中、下肺区的密度测定,并同时进行肺高分辨扫描(HRCT) ,分析二者的变化与CTD伴ILL的关系。结果 2 2 2例CTD患者中197例平均肺密度有不同程度的增高,2 5例平均肺密度正常。15 7例HRCT有不同程度的肺间质病变,6 5例HRCT正常。5 0名正常对照者HRCT均正常,8名平均肺密度有不同程度的增高,4 2名平均肺密度正常。结论 采用MSCT与HRCT对CTD伴ILL的检测结果差异有统计学意义,P =0 .0 0 0 (双侧) ,因此MSCT平均肺密度测定对早期诊断CTD伴ILL比HRCT更敏感,更有临床意义。
Objective To investigate the clinical significance of multislice spiral computed tomography (MSCT) for the early diagnosis of connective tissue disease (CTD) interstitial lung disease (ILL). Methods Twenty-two patients with CTD and 50 normal controls were enrolled in this study. Pulmonary density was measured by Pulmo automatic evaluation software attached to MSCT. High-resolution lung scan (HRCT) was performed at the same time. Relationship between CTD and ILL. Results In 222 cases of CTD, the average lung density of 197 patients increased to some extent, and 25 patients had normal average lung density. 15 7 cases of HRCT have varying degrees of interstitial lung disease, 65 cases of normal HRCT. Fifty normal controls were normal HRCT, eight average lung density increased to varying degrees, 42 average lung density was normal. Conclusion The results of CTD with ILL were significantly different between MSCT and HRCT, P = 0.0000 (bilateral). Therefore, the average density of MSCT was more sensitive to early diagnosis of CTD with ILL than HRCT, and more clinical significance.