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目的探究乳腺癌血管内皮生长因子C(VEGF-C)、血管内皮生长因子受体3(VEGFR-3)的表达与淋巴结转移之间的关系。方法取2006年10月至2010年4月我院接收治疗手术切除的乳腺浸润性导管癌标本54例为研究对象,另取10例乳腺纤维腺瘤标本作为对照,用免疫组化验查两组标本中VEGF-C、VEGFR-3的表达情况。结果乳腺癌组VEGF-C、VEGFR-3阳性表达率及表达程度均高于对照组;乳腺癌淋巴结转移阳性组VEGF-C、VEGFR-3表达率及表达程度均高于非淋巴结转移组,VEGF-C、VEGFR-3的表达与乳腺癌腋淋巴结转移呈正相关关系;VEGF-C与VEGFR-3的表达呈正相关关系。结论乳腺癌组织中VEGF-C、VEGFR-3表达增多,VEGF-C、VEGFR-3表达能有效促进乳腺癌淋巴结的转移。
Objective To investigate the relationship between the expression of vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor receptor 3 (VEGFR-3) and lymph node metastasis in breast cancer. Methods From October 2006 to April 2010, 54 cases of invasive ductal carcinoma of the breast received surgical resection in our hospital were selected as research objects. Another 10 cases of breast fibroadenoma specimens were used as controls. Two groups of specimens were examined by immunohistochemistry In VEGF-C, VEGFR-3 expression. Results The positive rate and the expression of VEGF-C and VEGFR-3 in breast cancer group were higher than those in control group. The positive rates of VEGF-C and VEGFR-3 in breast cancer with lymph node metastasis were significantly higher than those in non-lymph node metastasis The expression of VEGF-C and VEGFR-3 was positively correlated with axillary lymph node metastasis in breast cancer. The expression of VEGF-C and VEGFR-3 was positively correlated. Conclusion The expression of VEGF-C and VEGFR-3 in breast cancer tissues increased. The expression of VEGF-C and VEGFR-3 could effectively promote the lymph node metastasis in breast cancer.