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为探讨不同剂量甘露醇减轻脑水肿程度及对神经病理影响 ,将 40只新生猪随机分为正常对照组、缺氧缺血性脑损伤模型组 (HIBD组 )、小剂量 ( 0 5g kg)和大剂量 ( 2g kg)治疗组。四组均测颅内压 (ICP)、脑含水量 (BTWC)、血浆渗透压及病理检查。结果HIBD组BTWC及ICP较正常组明显增高 (P <0 .0 1 )。两治疗组各时相点ICP及BTWC明显低于HIBD组 ,且两治疗组ICP及BTWC下降程度无显著性差异 (P>0 .0 5 ) ,但大剂量组血浆渗透压较小剂量组明显增高 ,峰值达高渗状态 (P <0 0 1 )。表明甘露醇能减轻脑水肿 ,但对神经细胞不可逆改变无治疗作用。小剂量安全有效 ,用药时间 3～ 4小时为宜。监测血浆渗透压及ICP可指导甘露醇用量
In order to investigate the effect of different doses of mannitol on brain edema and neuropathological changes, 40 newborn pigs were randomly divided into normal control group, hypoxic-ischemic brain damage model group (HIBD group), low dose (0 5g kg) and High-dose (2g kg) treatment group. Four groups were measured intracranial pressure (ICP), brain water content (BTWC), plasma osmolality and pathological examination. Results The BTWC and ICP in HIBD group were significantly higher than those in normal group (P <0.01). The ICP and BTWC at each time point in the two treatment groups were significantly lower than those in the HIBD group, and there was no significant difference in ICP and BTWC between the two treatment groups (P> 0.05), but the plasma osmolality of the high-dose group was significantly lower than that of the low-dose group Increased, the peak reached hypertonic state (P <0 0 1). Mannitol can reduce brain edema, but irreversible changes in nerve cells without treatment. Small dose of safe and effective, medication time 3 ~ 4 hours is appropriate. Monitoring plasma osmolality and ICP can guide the mannitol dosage