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十年来,硝酸甘油敷贴治疗冠心病引起人们极大的兴趣.硝酸甘油分子小,敷贴后持续地迅速穿过皮肤,完全避免首次通过代谢,可长时间地保持必要的血药浓度.随着剂型的改进和储药囊的研制,药物的释出更合乎要求,临床应用当日益广泛.(一)硝酸酯对循环系统的影响和治疗冠心病的病理生理基础硝酸酯扩张周围血管和解除冠状动脉痉挛的作用强大,可对抗心肌缺血所致的许多病理生理后果.常规剂量下,硝酸酯主要扩张周围静脉;随着剂量的增大,硝酸酯还可扩
Ten years, nitroglycerin dressing treatment of coronary heart disease caused great interest.Nitroglycerin small molecules, continue to apply rapidly after the skin through the skin, completely through the metabolism for the first time, for a long time to maintain the necessary blood concentration. With the improvement of dosage form and the development of drug storage capsule, the release of drugs is more satisfactory and the clinical application is more and more widespread. (A) The influence of nitrates on the circulatory system and the pathophysiology of coronary heart disease Coronary spasm is powerful and can fight many pathophysiological consequences caused by myocardial ischemia. At conventional doses, nitrate mainly dilates the peripheral veins; with increasing doses, nitrates can also be expanded