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目的 :评价胺碘酮在治疗心房纤颤中对心肌复极的影响。方法 :测量了 4 8例用胺碘酮转复和维持治疗房颤患者的QT间期与QT离散度 ,并与 2 1例阵发房颤和 4 3例健康对照组比较。结果 :阵发房颤动组与健康对照组QT间期和QT离散度无差异 (QT :4 0 5± 4 4vs3 97+3 0ms .QTc :4 48± 4 7vs4 2 4± 2 6ms ,QTD 2 9± 1 7vs2 7± 1 6ms ,QTcD :2 8±1 9vs2 6± 1 8ms ,P >0 .0 5) ,但与前两对照组比 ,胺碘酮明显延长QT期间并使QTD增大 (QT :4 65± 53vs4 0 5± 4 4or3 97± 3 0ms ,QTc :4 49± 54vs4 48± 4 7or 4 2 4± 2 6ms ,QTD :4 7± 2 0vs2 9± 1 9or 2 7± 1 6ms ,QTcD :4 9± 2 1vs2 8± 1 9or 2 6± 1 8ms ,P <0 .0 1 )。结论 :胺碘酮不仅延长心肌复极 ,且使复极离散。
Objective: To evaluate the effect of amiodarone on myocardial repolarization in the treatment of atrial fibrillation. Methods: QT interval and QT dispersion of 48 patients treated with amiodarone and maintenance AF were measured and compared with 21 patients with paroxysmal atrial fibrillation and 43 healthy controls. Results: There was no difference in QT interval and QT dispersion between paroxysmal atrial fibrillation group and healthy control group (QT: 40 ± 4 4vs3 97 + 3 0ms. QTc: 4 48 ± 4 7vs4 2 4 ± 2 6ms, QTD 29 ± 1 7vs2 7 ± 1 6ms, QTcD 2 8 ± 1 9vs2 6 ± 1 8ms, P> 0.05), but compared with the former two groups, amiodarone significantly prolonged QT and increased QTD (QT : 4 65 ± 53 vs 4 0 5 ± 4 4 3 97 ± 3 0 ms, QTc: 4 49 ± 54 vs 4 48 ± 4 7 4 4 4 2 6 ms, QTD: 4 7 ± 2 0 vs 2 9 ± 1 9 2 7 ± 1 6 ms, QTcD : 4 9 ± 2 1 vs 2 8 ± 1 9or 2 6 ± 1 8ms, P <0.01). Conclusions: Amiodarone not only prolonged myocardial repolarization but also repolarization.