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原发性胆汁性肝硬化(PBC)是一种自身免疫性疾病,以肝内胆管进行性破坏、慢性胆汁淤积为主要特征。PBC的发病机制复杂,涉及遗传易感性、免疫机制、感染因素及化学物质等。了解PBC的发病机制对于采取正确合理的治疗方案,降低其发病率和病死率意义重大。其中免疫机制与机体产生的自身抗体及免疫细胞分泌的多种细胞因子相关。本文就免疫因素在PBC发病机制中的作用进行综述。
Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile duct and chronic cholestasis. The pathogenesis of PBC is complex, involving genetic susceptibility, immune mechanisms, infectious agents and chemical substances. To understand the pathogenesis of PBC for the right and reasonable treatment programs to reduce their morbidity and mortality is of great significance. The immune mechanism and the body’s autoantibodies and immune cells to secrete a variety of cytokines. This article reviews the role of immune factors in the pathogenesis of PBC.