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尿毒症病人表现全身各器官功能紊乱,呈现神经、消化、血液、循环、呼吸、泌尿等系统的多种症状和体征。这些症状和体征常被归咎于尿毒素。尿毒素究竟是什么?近几年来,由于使用现代化仪器,如气—液色谱、质谱法等,已从尿毒症血液分离到200多种代谢产物,其中100多种在尿毒症时特有或比正常值高。现认为主要是一些蛋白质的代谢产物,其中尤以胍类如甲基胍、胍基琥珀酸及一些未知结构的中分子物质的积聚尤为人们所注意,而尿素,肌酐、
Patients with uremia manifestations of systemic organ dysfunction, showing a variety of neurological, digestive, blood, circulatory, respiratory, urinary system and other symptoms and signs. These symptoms and signs are often attributed to urinary toxins. In recent years, more than 200 kinds of metabolites have been isolated from uremic blood due to the use of modern instruments such as gas-liquid chromatography and mass spectrometry, of which more than 100 are unique or more specific than normal in uremia High value. Now that the main is the metabolism of some proteins, especially in guanidine such as methyl guanidine, guanidinesuccinic acid and some unknown structure of the accumulation of the middle molecular substances is particularly noticeable, and urea, creatinine,