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为探讨服用抗嘌呤代谢药物期间测定红细胞内硫鸟嘌呤核苷酸 (ＴＧＮ)浓度对实现抗嘌呤代谢药物剂量个体化的作用 ,我们在急性淋巴细胞白血病 (ＡＬＬ)患儿服用 6 巯基嘌呤(6 ＭＰ)期间 ,用高效液相色谱仪测定红细胞内硫鸟嘌呤核苷酸的浓度 ,现报道如下。对象和方法1 观察对
To investigate the effect of thioguanine nucleotide (TGN) concentration in erythrocytes on the individualization of dose of anti-purine metabolism during anti-purine metabolism, we took 6-mercaptopurine (6) in children with acute lymphoblastic leukemia (ALL) MP), high-performance liquid chromatography determination of erythrocyte thioguanine nucleotide concentration, are reported below. Objects and methods 1 observed right